Learn about the new drug for the treatment of anemia Jesduvroq, general information about it, when to use it, and what are its benefits and harms

Jesduvroq A new treatment for anemia

Information about Jesduvroq

Jesduvroq (daprodustat) tablets are used to treat anemia (poor red blood cells) in dialysis patients that are brought on by chronic kidney disease (CKD). Red blood cell (RBC) transfusions are lessened or avoided using jesduvroq.

Jesduvroq functions by raising erythropoietin, a hormone that instructs the body to produce more red blood cells. Jesduvroq is a prolyl hydroxylase inhibitor of hypoxia-inducible factor (HIF-PHI).

Jesduvroq pills should be taken once daily orally. The only other FDA-approved therapy for this illness requires an injection into the blood or application to the skin; jesduvroq is the only oral medication for treating anemia brought on by CKD.

Jesduvroq has not been shown to increase well-being, quality of life, or fatigue in clinical research. It is not advised to use Jesduvroq In the following cases:

Instead of immediate anemia therapy (red blood cell transfusions).
For the treatment of CKD-related anemia in individuals not receiving dialysis.

How does the new treatment for anemia work, Jesduvroq?

Chronic kidney disease patients may need dialysis, a treatment that filters the blood and removes excess fluid. A hormone called erythropoietin is also produced by the kidneys and instructs the body to manufacture red blood cells. When patients with chronic kidney disease are on dialysis, their kidneys often cannot produce enough erythropoietin, so their number of red blood cells becomes low. Jesduvroq treats anemia by increasing erythropoietin levels, which messages the body to make more red blood cells. The blood test for anemia measures hemoglobin level, a protein in red blood cells.

Technically speaking, Jesduvroq is an inhibitor of the hypoxia-inducible factor prolyl hydroxylase (HIF-PHI). Inhibition of oxygen-sensing prolyl hydroxylase enzymes stabilizes hypoxia-inducible factors, and this can lead to the transcription of erythropoietin and other genes involved in treating the anemia.

Your hemoglobin level can become dangerously high or rise too rapidly, which can cause major health issues and even death. Even if your hemoglobin levels do not rise while using Jesduvroq, these severe health issues might still occur.

Who may own Jesduvroq?

According to the FDA, adults receiving dialysis for at least four months and having anemia (few red blood cells) brought on by chronic renal disease are eligible to receive the treatment of anemia Jesduvroq.

Jesduvroq is exclusively FDA-approved for dialysis patients; those not receiving dialysis cannot use it.


Jesduvroq may have severe adverse consequences, such as:

The risk of mortality, heart attack, stroke, and blood clots increases. These hazards might occur if you receive Jesduvroq treatment to raise red blood cells (RBCs) to a level close to that of healthy individuals. These risks might be raised if you have issues with your heart, blood vessels, or brain blood flow (cerebrovascular disease). Deep vein thrombosis (DVT), pulmonary embolism (PE), and dialysis access are only a few of the blood channels (veins) where blood clots can develop (vascular access thrombosis or VAT). Technically speaking, Jesduvroq is an inhibitor of the hypoxia-inducible factor prolyl hydroxylase (HIF-PHI). Go to the doctor quickly if you experience any of the following conditions:

  • A chest ache

  • Unusual coldness or warmth in your arm or leg, shortness of breath, difficulty breathing, abrupt difficulty walking, dizziness, loss of balance, or lack of coordination, and discomfort in your leg or arm with or without swelling

  • access to dialysis ceases functioning

  • You won't experience a vibration ("thrill") over the dialysis access region if you experience sudden bewilderment, difficulty speaking, or difficulty comprehending others' speech.

  • Sudden numbness or weakness, especially on one side of your body, in your face, arm, or leg

For further details on side effects, see "What are the adverse effects of the treatment of anemia Jesduvroq?"

If you choose to use Jesduvroq, your doctor should recommend the smallest dosage possible to lower your risk of requiring red blood cell transfusions.

Situations where the treatment of anemia Jesduvroq is forbidden

Jesduvroq should not be used if you:

  • Take some drugs referred to as powerful CYP2C8 inhibitors, including gemfibrozil. If you're unsure, consult your healthcare professional.

  • Having uncontrolled high blood pressure (uncontrolled hypertension)

  • Jesduvroq is not advised in cases of serious liver damage.

  • Jesduvroq has been rejected.

What must I discuss with my doctor before starting Jesduvroq?

You must disclose to your doctor all of your present and prior medical problems before using this medication, including:

  • cardiac conditions, a history of heart failure, and a stroke

  • blood pressure is high.

  • Stomach ulcers have a history of harm to the lining of the stomach, esophagus (the tube connecting the mouth and stomach), or intestines (peptic ulcer disease)

  • consume booze or smoke cigarettes

  • have liver issues and cancer

  • either has plans to get pregnant or is already expecting.


Jesduvroq could be bad for the unborn child.

If you get pregnant while taking this medication or suspect that you might be pregnant, you should immediately contact your healthcare practitioner.


It is unknown if this medication goes into your breast milk if you are or want to breastfeed. Do not breastfeed while receiving Jesduvroq therapy, or for 1 week following your last dosage.

Details on Dose

Please take this medication precisely as prescribed by your doctor.

  • Jesduvroq comes as an oral tablet in five strengths: 1 mg, 2 mg, 4 mg, 6 mg, and 8 mg.
  • Jesquvroq should be taken once daily as directed, with or without meals.
  • Do not cut, chew, or crush pills; swallow them whole.
  • If necessary, Jesduvroq can be used along with phosphate binders or iron supplements that regulate the quantity of phosphorus in your blood.
  • Jesduvroq can be given regardless of the frequency or kind of dialysis.
  • Never alter your medication's dosage without consulting your healthcare professional, or stop taking it altogether.

Before taking Jesduvroq and as needed throughout therapy, your doctor will order a few blood tests. Your healthcare practitioner could adjust the dosage of this medication based on the findings of your blood tests.

What occurs if I don't take a dose?

Unless it is the same day as your next dosage, take the missed dose of this medication as soon as you recall. If your next dosage is the same day as the missed one, skip the missed dose and take the regular time for your next dose.

Avoid taking two doses at once to make up for a missing dosage.

If I take too much, what happens?

If you take more Jesduvroq than is recommended, you should immediately call your doctor or head to the emergency department of the closest hospital.

What negative consequences does Jesduvroq have?

Jesduvroq's severe adverse effects include the following:

  • The "Warnings" section is also above.
  • Heart failure hospitalization risk. When using this medication, people with a history of heart failure are more likely to end up in the hospital with the condition. If your heart failure symptoms worsen, you should immediately notify your healthcare physician. Some symptoms include:
  • swelling in your legs, ankles, or feet, breathing difficulties, or shortness of breath
  • feeling tired or weak, gaining weight quickly

Elevated blood pressure Jesduvroq frequently causes adverse effects, including high blood pressure. When using Jesduvroq, your blood pressure may increase and become more challenging to manage. Over the course of your medication therapy, your healthcare professional should routinely monitor your blood pressure. If your blood pressure rises, your doctor may advise you to take a different medication or adjust the dosage you already use.

Injury to the lining of the intestines, the esophagus, and the tube connecting the mouth and the stomach (gastrointestinal erosion). If you have ever experienced gastrointestinal erosion or stomach ulcers (peptic ulcer disease), used certain medications that enhance the risk of gastrointestinal erosion, smoked cigarettes, or used alcohol, your chance of developing gastrointestinal erosion may rise. Transfusions could be required for specific persons with stomach and intestinal bleeding. Describe to your medical professional any of the following symptoms:

  • Abdominal pain or discomfort in the stomach region

  • nausea or vomiting,

  • dark tarry stools

  • stools discomfort

Cancer. Jesduvroq therapy has resulted in cancer cases in patients. If you have any worries about cancer, speak with your doctor.

Jesduvroq's most frequent adverse effects include the following:

  • Elevated blood pressure

  • Heart attack, stroke, and blood clots in the legs, lungs, or dialysis access. Read details under "Warnings" above.

  • Abdominal discomfort in the stomach region.

These are not the only adverse effects of this medication that may occur. For medical advice concerning side effects.

Which medications will interact with Jesduvroq?

Include all medications you use, including prescription and over-the-counter drugs, vitamins, and herbal supplements, with your healthcare physician.

When some other medications are used with Jesduvroq, it may change how those other medications operate and have an adverse effect. Some medications that are processed in a specific way interact with jesduvroq. Inform your doctor if you are using any of the following drugs.:

Clopidogrel and gemfibrozil (Lopid), two CYP2C8 inhibitors (Plavix)

Inducers of CYP2C8: rifampin (Rifadin)

This is not an exhaustive list. Jesduvroq may interact with various medications; however, not all possible interactions are included in this medication guide.

General information about using Jesduvroq safely and effectively.

Sometimes, doctors prescribe drugs for uses not included in the Drug Information Booklet. Jesduvroq should not be used for any ailment that has not been prescribed. Even if they exhibit the same symptoms as you, avoid giving this medication to others as it might cause harm. For information about this medication intended for healthcare professionals, speak with your pharmacist, doctor, or other sources of healthcare.


Jesduvroq should be kept between 68 °F and 77 °F (20 °C and 25 °C) at room temperature.

Jesduvroq and other medications must be kept out of children's reach.

What components make up Jesduvroq?

The active component is daprodustat.

Among the inactive ingredients are colloid silicon dioxide, croscarmellose sodium, hypromellose, magnesium stearate, mannitol, and microcrystalline cellulose. Iron oxide red and iron oxide yellow (1 mg, 2 mg, 6 mg, and 8 mg tablets), titanium dioxide, hypromellose, and polyethylene glycol are the ingredients in the tablet film coating.

The company that made Jesduvroq

GlaxoSmithKline Durham

The-Optix Medical
By : The-Optix Medical
Mohanad Seif, Doctor of Pharmacist, I seek to make people's lives beautiful and distinguished by delving into daily medical and health life. I grab helpful information and news and present it to everyone through The-Optix.

Font Size
lines height